Severe, persistent pain in the upper abdomen — often boring through to the back — with nausea and vomiting that will not stop. That is the pancreatitis pattern.
Stop and seek medical assessment. Persistent vomiting also dehydrates and strains the kidneys — sip fluids.
Unrelenting abdominal pain, repeated vomiting, or signs of dehydration → urgent care or ER. And tell any anaesthetist before surgery: these drugs slow stomach emptying and raise the risk of aspiration under anaesthesia.
Allergic reaction: hives, swelling of the lips, tongue or throat, wheezing or dizziness can escalate to anaphylaxis within minutes — call 911 immediately. Site infection: spreading redness, heat, swelling, pus or fever is not wait-and-see; an abscess or cellulitis can need drainage or IV antibiotics. Unverified product: grey-market vials are frequently mislabelled or contaminated, so a reaction may be to endotoxin or the wrong contents, not the named compound.
Amylin is co-secreted with insulin by beta cells and signals satiety through the area postrema. Cagrilintide is a long-acting analog engineered for weekly administration, acting at amylin and calcitonin receptor complexes. Its interest lies in a satiety mechanism largely orthogonal to GLP-1, which is why it is being developed in combination with semaglutide (CagriSema).
Phase 2 established weight effects as monotherapy and in combination. Phase 3 combination programmes are ongoing and have reported mixed results against expectations. Not established.
Not approved. Investigational.
Under investigation. Gastrointestinal effects reported in trials. Human safety not established.
Investigational. Phase 2 titrated to 2.4 mg once weekly SC, alone and combined with semaglutide (CagriSema). Not an established dose.
Reported from clinical trials or FDA labelling as a matter of record. It is not a recommendation, and for unapproved compounds no dose has been shown safe or effective in humans.
Above is what was administered in trials or on FDA labels, reported as fact. We do not convert it into a personal protocol, calculate a dose for your body weight, or tell you what to inject or how to reconstitute it — that decision belongs with a licensed physician. See our editorial policy.
Regulatory status changes. This page reflects our reading of public sources as of July 2026 and should be independently verified before it is relied upon.