Any new or unusual symptom after dosing. Because this compound has little or no human safety data, there is no established list of 'expected' effects to reassure you against — treat anything abnormal as a signal.
Stop at the first clearly abnormal reaction and reassess. Keep the vial and lot number in case you need to describe what you actually took.
Any severe or fast-worsening symptom — difficulty breathing, chest pain, fainting, severe pain — is a 911 call regardless of the compound.
Allergic reaction: hives, swelling of the lips, tongue or throat, wheezing or dizziness can escalate to anaphylaxis within minutes — call 911 immediately. Site infection: spreading redness, heat, swelling, pus or fever is not wait-and-see; an abscess or cellulitis can need drainage or IV antibiotics. Unverified product: grey-market vials are frequently mislabelled or contaminated, so a reaction may be to endotoxin or the wrong contents, not the named compound.
Inhibits nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide and marks it for excretion. Inhibiting NNMT should preserve nicotinamide for NAD+ salvage — raising NAD+ — while also affecting methyl-group balance and adipocyte metabolism. NNMT is overexpressed in the adipose tissue of obese individuals, which is the origin of the interest.
Rodent work reports reduced adiposity in diet-induced obese mice without altered food intake. That is essentially the entire evidence base. There are no human trials. The distance between one mouse finding and the marketing claims made for this compound is among the largest in this library.
Not FDA-approved. Not a lawful dietary supplement. Sold as a research chemical.
No human safety data whatsoever. NNMT sits at a junction of NAD+ metabolism and methyl-group homeostasis, and inhibiting it chronically has consequences nobody has characterised in humans.
No human trial has ever established a dose for this compound. Any figure circulating online is extrapolated from animal studies or copied between vendors — it was not validated in people. That absence is the single most important dosing fact on this page. Dosing exists only in mouse studies.
Reported from clinical trials or FDA labelling as a matter of record. It is not a recommendation, and for unapproved compounds no dose has been shown safe or effective in humans.
Above is what was administered in trials or on FDA labels, reported as fact. We do not convert it into a personal protocol, calculate a dose for your body weight, or tell you what to inject or how to reconstitute it — that decision belongs with a licensed physician. See our editorial policy.
Regulatory status changes. This page reflects our reading of public sources as of July 2026 and should be independently verified before it is relied upon.